Hair loss can take a real toll on confidence, especially when it’s linked to inflammation and long-term follicle damage. At Doghurst Clinic in Chipstead, we’re using polynucleotides for hair regrowth in scarring alopecia — an advanced regenerative treatment designed to calm inflammation, repair scalp tissue, and encourage new hair growth.
This innovative approach supports natural healing from within, helping restore both scalp health and confidence for patients experiencing thinning or patchy areas due to chronic inflammatory hair loss.
What Are Polynucleotides?
Polynucleotides (often called “PNs”) are highly purified chains of DNA fragments — the fundamental building blocks of life. They’re extracted from purified salmon or trout DNA (a remarkably biocompatible source) and processed to pharmaceutical-grade standards to ensure they are completely sterile, safe, and non-allergenic.
Unlike traditional filler or stimulant treatments, polynucleotides don’t simply “fill” or “freeze” anything — they work at a cellular level to improve the quality and function of the tissues they’re injected into.
Learn more about regenerative options like aesthetic and skin treatments at Doghurst Clinic.
How Do They Work?
When injected into the scalp or skin, polynucleotides act as powerful bio-stimulants. They encourage:
- Cell repair and regeneration, stimulating fibroblasts to produce collagen and restore tissue integrity.
- Improved circulation, enhancing oxygen and nutrient delivery to hair follicles.
- Reduction in inflammation, calming the immune activity that can damage follicles over time.
- Enhanced hydration of the scalp and skin barrier, creating a healthier environment for hair growth.
You can read more about how they work in the peer-reviewed article Polynucleotides in Aesthetic Medicine: A Review of Current Applications published in MDPI (2024).
Why Are They Safe?
Polynucleotides have been used safely in medicine for more than 30 years, particularly in ophthalmology and wound healing. They are biocompatible, biodegradable, and free from synthetic additives, meaning the body recognises them as its own. Once their regenerative work is complete, they naturally break down into harmless components that your cells can reuse.
All products used at Doghurst Clinic are CE-marked medical devices, sourced from trusted UK suppliers and prepared to the highest sterility standards.
Understanding Scarring Alopecia
Our client’s hair loss was caused by scarring alopecia, also known as cicatricial alopecia — a relatively uncommon but important group of hair loss conditions.
In scarring alopecia, inflammation attacks and damages the hair follicles, sometimes leading to permanent scarring and thinning in affected areas. It accounts for only 3–7% of all hair loss cases, but can have a profound emotional and physical impact.
There are several subtypes, including:
- Lichen planopilaris (LPP)
- Frontal fibrosing alopecia (FFA) — often affecting women after menopause
- Discoid lupus erythematosus (DLE)
Learn more from the British Association of Dermatologists – Frontal Fibrosing Alopecia
and BAD – Central Centrifugal Cicatricial Alopecia.
Because inflammation plays such a key role, treatment usually focuses on calming the immune response and protecting remaining follicles. This made polynucleotides a particularly interesting option to explore, given their anti-inflammatory and tissue-repairing properties.
For more on scalp and skin conditions, visit our Dermatology services.
A Real-World Case at Doghurst Clinic
One of our clients came to us with a chronic inflammatory scalp condition causing scarring alopecia and visible redness along the hairline.
After a thorough consultation, we agreed to trial a course of polynucleotide injections, spaced 2–3 weeks apart, to calm inflammation, repair the follicle environment, and support new growth.
- Treatment start: April 2025
- Treatment completion: October 2025
Below 6 months after treatment with less inflammation and less scalp visible.
Picture remains the property of Doghurst Clinic
Picture remains the property of Doghurst Clinic
Right shows less scalp visible and new hair regrowing.
Picture remains the property of Doghurst Clinic
Right shows During treatment, the client didn’t notice any dramatic changes — which is entirely normal given the slow growth cycle of hair.
However, when we compared the before and after photographs, the results spoke for themselves:
- The red, inflamed spots along the hairline had completely settled.
- The scalp appeared less visible, with improved hair density and coverage.
- Once shown the photos, the client was delighted with the subtle yet clear improvement.
Read more about the science in this PubMed-indexed study showing how polynucleotides may support follicle recovery.
What This Means for Hair Health
While every scalp and every diagnosis is unique, this case highlights the potential of regenerative injectables to support both healing and hair restoration — even in conditions where scarring and inflammation are central.
At Doghurst Clinic, we combine medical insight with the latest regenerative technologies to help our patients regain both scalp health and confidence.
Clinical management of hair disorders often follows NICE guidance on hair loss, ensuring treatments are evidence-based and patient-centred.
If you’re struggling with hair thinning or scalp inflammation, a consultation with our GP can help determine whether polynucleotides, PRP, or other regenerative treatments could support your recovery.
📞 Book Your Consultation
Interested in exploring hair restoration or scalp rejuvenation?
Call 0208 660 9219 or visit doghurstclinic.co.uk to book your personalised consultation today.
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